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<br><br><h3>Other images<br> from the same article</h3><a href="http://www.antibodyreview.com/article_images/15693955/Genome%20Biol/6-2/p208-551527/gb-2005-6-2-208-1.jpg" class="highslide" onclick="return hs.expand(this)">
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A proposed pathway for anaerobic oxidation of methane involving the 
homolog of methyl CoM reductase and a novel methylene 
tetrahydromethanopterin (H4MPT) reductase (Mer), and its connection with
 the sulfate reduction pathway... <br><br>
Article : A genomic view of methane oxidation by aerobic bacteria and anaerobic archaea<br>
<a onclick="window.open(this.href); return false;" href="http://genomebiology.com/2005/6/2/208" target="_blank">Genome Biol. 2005 Feb 1; 6(2):208</a><br><br>
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Pathways in the aerobic methanotrophic bacterium Methylococcus 
capsulatus involved in the metabolism of single carbon compounds, as 
determined by genome sequencing and proteome analysis... <br><br>
Article : A genomic view of methane oxidation by aerobic bacteria and anaerobic archaea<br>
<a onclick="window.open(this.href); return false;" href="http://genomebiology.com/2005/6/2/208" target="_blank">Genome Biol. 2005 Feb 1; 6(2):208</a><br><br>
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<strong>Figure 1.</strong>A proposed pathway for anaerobic oxidation of 
methane involving the homolog of methyl CoM reductase and a novel 
methylene tetrahydromethanopterin (H4MPT) reductase (Mer), and its 
connection with the sulfate reduction pathway. A proposed pathway for 
anaerobic oxidation of methane involving the homolog of methyl CoM 
reductase and a novel methylene tetrahydromethanopterin (H4MPT) 
reductase (Mer), and its connection with the sulfate reduction pathway. 
(a) The reverse methanogenesis pathway. Solid arrows represent enzymes 
predicted from the sequences found by Hallam et al. [3 ; the dotted 
arrow represents the one enzyme that was not predicted, methylene H4MPT 
reductase (Mer). Enzymes performing steps 1 7: 1, Methyl CoM reductase 
like protein (MCR); 2, Methyl H4MPT:coenzyme M (CoM) methyl transferase 
(Mtr); 3, Methylene H4MPT reductase (Mer); 4, F420 dependent methylene 
H4MPT dehydrogenase (Mtd); 5, Methenyl H4MPT cyclohydrolase (Mch); 6, 
Formyl MFR:H4MPT formyltransferase (Ftr); 7, Formyl MFR dehydrogenase 
(Fmd). (b) Reverse methanogenesis is thought to be connected to sulfate 
reduction through an unknown intermediate (X); e  represents an 
electron. Hallam et al. [3  suggest that steps 1 and 2 in (a) function 
in the down direction and methyl H4MPT is used for biomass generation 
(c), while steps 4 to 7 function in the up direction and the methylene 
H4MPT produced is either converted to biomass through the serine cycle 
or is oxidized to CO2. We suggest that Mer or an analogous enzyme 
probably performs step 3 instead..<br><br>
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	    <td colspan="3" height="25" valign="middle"><strong><u>Image Reference </u></strong></td>
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	  <tr height="25"><td colspan="3" valign="top">A genomic view of methane oxidation by aerobic bacteria and anaerobic archaea</td>
	</tr>
		  <tr height="25"> <td colspan="3" valign="top"><a onclick="recordOutboundLink(this, 'Outbound Links', 'http://genomebiology.com/2005/6/2/208');return false;" href="http://genomebiology.com/2005/6/2/208"><strong>Genome Biol. 2005 Feb 1; 6(2):208</strong></a></td>
	  </tr>
	  <tr height="25"><td height="42" valign="top"><strong>Abstract</strong></td>
	  <td valign="top"><a href="javascript:check_visible()"><div id="view" style="visibility: visible;"><strong>[+]</strong></div><div id="hide" style="visibility: hidden;"><strong>[-]</strong></div></a></td>
	  <td style="width: auto;">
	  <div style="visibility: visible; height: 20px;" id="iabstract">Recent
 sequencing of the genome and proteomic analysis of a model aerobic 
methanotrophic bacterium, Methylococcus capsulatus (Bath) has revealed a
 hig.....</div>
	 	    <div style="visibility: hidden; height: 20px;" id="abstract">Recent
 sequencing of the genome and proteomic analysis of a model aerobic 
methanotrophic bacterium, Methylococcus capsulatus (Bath) has revealed a
 highly versatile metabolic potential. In parallel, environmental 
genomics has provided glimpses into anaerobic methane oxidation by 
certain archaea, further supporting the hypothesis of reverse 
methanogenesis.</div><br></td>
	  </tr>

	  <tr height="25"><td colspan="3" valign="top">Copyright    2005 BioMed Central Ltd<br>
</td>
	  </tr>
	  
	  <tr height="25"><td valign="top"><strong>Keywords</strong></td>
	  <td colspan="2" valign="top"><strong>:</strong>	    MFR</td>
	  </tr>
	  </tbody></table>
					
				
			
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